Evaluating staging laparoscopy indications for pancreatic cancer based on resectability classification and treatment strategies for patients with positive peritoneal washing cytology

Introduction The prognosis of pancreatic ductal adenocarcinoma (PDAC) in patients with positive peritoneal washing cytology (CY1) is poor. We aimed to evaluate the results staging laparoscopy (SL) and treatment efficacy CY1 based on a resectability classification. Methods retrospectively reviewed 250 PDAC who underwent SL before initial between 2017 2023 at University Toyama. Results breakdown cases by classification was resectable (R):borderline (BR):unresectable locally advanced (UR-LA) = 131:48:71 cases. frequency increased proportion degree local progression (R:BR:UR-LA 20:23:34%), but frequencies liver metastasis or dissemination were comparable 6.9:6.3:8.5%). Most received gemcitabine along nab-paclitaxel therapy. CY-negative conversion rates 70:64:52%) surgery 40:27:9%) inversely proportional progression. Comparing H0P0CY1 factors for each classification, had significantly more body tail carcinoma tumor size ≥32 mm R patients, whereas BR duke monoclonal antigen type 2 (DUPAN-2) ≥ 230 U/mL significant factor. In contrast, no observed UR-LA patients. Conclusion rates, varied according case BR, could be considered carcinoma, large size, high DUPAN-2 level. UR-LA, might all